Detalhe da pesquisa
1.
Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Cell
; 183(2): 335-346.e13, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035452
2.
Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential.
Trends Biochem Sci
; 43(9): 700-713, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30057142
3.
Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2.
J Pharmacol Exp Ther
; 376(3): 358-373, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33468641
4.
Magnesium modulates actin binding and ADP release in myosin motors.
J Biol Chem
; 289(34): 23977-91, 2014 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006251
5.
Temperature dependence of internal friction in enzyme reactions.
FASEB J
; 25(8): 2804-13, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21555355
6.
Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues.
J Pharm Biomed Anal
; 204: 114246, 2021 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34271288
7.
Relating the shape of protein binding sites to binding affinity profiles: is there an association?
BMC Struct Biol
; 10: 32, 2010 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20923553
8.
Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers.
Front Physiol
; 11: 144, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32265723
9.
Molecular tattoo: subcellular confinement of drug effects.
Chem Biol
; 22(4): 548-558, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25892202